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Article

Network-guided search for genetic heterogeneity between gene pairs.

Bioinformatics (Oxford, England) - 9 Apr 2021

Gumpinger Anja C, Rieck Bastian, Grimm Dominik G, Borgwardt Karsten

Abstract excerpt

MOTIVATION: Correlating genetic loci with a disease phenotype is a common approach to improve our understanding of the genetics underlying complex diseases. Standard analyses mostly ignore two aspects, namely genetic heterogeneity and interactions between loci. Genetic heterogeneity, the phenomenon that genetic variants at different loci lead to the same phenotype, promises to increase statistical power by...

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Identifiers

PMID: 32573681
DOI: 10.1093/bioinformatics/btaa581
PMCID: PMC8034561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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