Article
Hal2p functions in Bdf1p-involved salt stress response in Saccharomyces cerevisiae.
PloS one - 1 Jan 2013
Chen Lei, Liu Liangyu, Wang Mingpeng, Fu Jiafang, Zhang Zhaojie, Hou Jin, Bao Xiaoming
Abstract excerpt
The Saccharomyces cerevisiae Bdf1p associates with the basal transcription complexes TFIID and acts as a transcriptional regulator. Lack of Bdf1p is salt sensitive and displays abnormal mitochondrial function. The nucleotidase Hal2p detoxifies the toxic compound 3' -phosphoadenosine-5'-phosphate (pAp), which blocks the biosynthesis of methionine. Hal2p is also a target of high concentration of Na(+). Here, we...
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