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A highly conserved two-gene operon is crucial for lipoarabinomannan localization, pathogenesis, and cell envelope function in <i>Mycobacterium abscessus</i>

2026-01-29

Abstract excerpt

Mycobacterium abscessus is an emerging threat, causing infections that are difficult to treat due to intrinsic resistance to most antibiotics. Determinants of M. abscessus physiology and pathogenesis remain poorly understood, hampering therapeutic development. Here, we show that in M. abscessus , the lprg-mfs operon is essential for virulence in macrophages and in mice. Loss of lprg-mfs in M. abscessus causes...

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Literature Corpus work
ceedb978-86cc-5112-a54f-5e778f129ec8
DOI
10.64898/2026.01.29.702501
Open publication

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