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Article

Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis.

Circulation research - 23 Jul 2010

Cheng Su-Li, Shao Jian-Su, Halstead Linda R, Distelhorst Kathryn, Sierra Oscar, Towler Dwight A

Abstract excerpt

RATIONALE: Vascular fibrosis and calcification contribute to diabetic arteriosclerosis, impairing Windkessel physiology necessary for distal tissue perfusion. Wnt family members, upregulated in arteries by the low-grade inflammation of "diabesity," stimulate type I collagen expression and osteoge...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multipotent Stem Cells

Share to Receptor, Parathyroid Hormone, Type 1

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Source

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Identifiers

PMID: 20489161
DOI: 10.1161/CIRCRESAHA.110.219899
PMCID: PMC2913587

Genes

LDLR
PTH
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20489161-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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