Article
A susceptibility gene for kidney disease in an obese mouse model of type II diabetes maps to chromosome 8.
Kidney international - 1 Sept 2010
Chua Streamson, Li Yifu, Liu Shun Mei, Liu Ruijie, Chan Ka Tak, Martino Jeremiah, Zheng Zongyu, Susztak Katalin, D'Agati Vivette D, Gharavi Ali G
Abstract excerpt
Most mouse models of diabetes do not fully reproduce features of human diabetic nephropathy, limiting their utility in inferring mechanisms of human disease. Here we performed detailed phenotypic and genetic characterization of leptin-receptor (Lepr) deficient mice on the FVB/NJ background (FVB(db/db)), an obese model of type II diabetes, to determine their suitability to model human diabetic nephropathy. These...
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