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Article

Genetic Analysis of Diffuse High-Grade Astrocytomas in Infancy Defines a Novel Molecular Entity.

Brain pathology (Zurich, Switzerland) - 1 Jul 2015

Gielen Gerrit H, Gessi Marco, Buttarelli Francesca R, Baldi Caterina, Hammes Jennifer, zur Muehlen Anja, Doerner Evelyn, Denkhaus Dorota, Warmuth-Metz Monika, Giangaspero Felice, Lauriola Libero, von Bueren André O, Kramm Christof M, Waha Andreas, Pietsch Torsten

Abstract excerpt

Pediatric high-grade gliomas are considered to be different when compared to adult high-grade gliomas in their pathogenesis and biological behavior. Recently, common genetic alterations, including mutations in the H3F3A/ATRX/DAXX pathway, have been described in approximately 30% of the pediatric cases. However, only few cases of infant high-grade gliomas have been analyzed so far. We investigated the molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25231549
DOI: 10.1111/bpa.12210
PMCID: PMC8029085

Genes

MIP
ATRX
DAXX
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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