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Article

Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Jun 2010

Paugh Barbara S, Qu Chunxu, Jones Chris, Liu Zhaoli, Adamowicz-Brice Martyna, Zhang Junyuan, Bax Dorine A, Coyle Beth, Barrow Jennifer, Hargrave Darren, Lowe James, Gajjar Amar, Zhao Wei, Broniscer Alberto, Ellison David W, Grundy Richard G, Baker Suzanne J

Abstract excerpt

PURPOSE: To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG). PATIENTS AND METHODS: We conducted a high-resolution analysis of genomic imbalances in 78 de novo pediatric HGGs, including seven diffuse intrinsic pontine gliomas, and 10 HGGs arising in children who received cranial irradiation for a previous cancer using single nucleotide polymorphism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20479398
DOI: 10.1200/JCO.2009.26.7252
PMCID: PMC2903336

Genes

PDGFRA
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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