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Article

FCGR2C genotyping by pyrosequencing reveals linkage disequilibrium with FCGR3A V158F and FCGR2A H131R polymorphisms in a Caucasian population.

mAbs - 1 Jan 2000

Lejeune Julien, Piègu Benoît, Gouilleux-Gruart Valérie, Ohresser Marc, Watier Hervé, Thibault Gilles

Abstract excerpt

The FCGR3A-V158F and FCGR2A-H131R polymorphisms are associated with clinical responses to therapeutic mAbs and with immune thrombocytopenic purpura (ITP). The FCGR2C-ORF/STOP polymorphism, controlling FcγRIIC expression on natural killer cells and therefore FcγRIIC-mediated antibody dependent cell-mediated cytotoxicity, is also associated with ITP. Using a new pyrosequencing assay to determine this polymorphism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

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Share to Purpura, Thrombocytopenic, Idiopathic

Share to Receptors, IgG

Share to Sequence Analysis, DNA

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Source

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Identifiers

PMID: 23032993
DOI: 10.4161/mabs.22287
PMCID: PMC3502245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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