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Article

Folate-related polymorphisms in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome.

European journal of human genetics : EJHG - 1 Jun 2015

Angelini Sabrina, Ravegnini Gloria, Nannini Margherita, Bermejo Justo Lorenzo, Musti Muriel, Pantaleo Maria A, Fumagalli Elena, Venturoli Nicola, Palassini Elena, Consolini Nicola, Casali Paolo G, Biasco Guido, Hrelia Patrizia

Abstract excerpt

The folate metabolism pathway has a crucial role in tumorigenesis as it supports numerous critical intracellular reactions, including DNA synthesis, repair, and methylation. Despite its importance, little is known about the influence of the folate pathway on gastrointestinal stromal tumour (GIST), a rare tumour with an incidence ranging between 6 and 19.6 cases per million worldwide. The importance of folate...

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Identifiers

PMID: 25227144
DOI: 10.1038/ejhg.2014.198
PMCID: PMC4795063

Genes

SHMT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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