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Article

Role of MTHFR polymorphisms and folate levels in different phenotypes of sporadic colorectal cancers.

International journal of colorectal disease - 1 May 2007

Chang Shih-Ching, Lin Pei-Ching, Lin Jen-Kou, Yang Shung-Haur, Wang Huann-Sheng, Li Anna Fen-Yau

Abstract excerpt

BACKGROUND AND AIMS: By altering both DNA methylation and nucleotide synthesis, folate metabolism is thought to contribute to colorectal carcinogenesis. We examined the role of folate metabolism in three different phenotypes of sporadic colorectal cancers (CRCs), phenotypes that were classified by the status of microsatellite instability (MSI) and chromosomal instability (CIN): MSI-H, microsatellite stability...

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Source

Identifiers

PMID: 16941173
DOI: 10.1007/s00384-006-0190-x

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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