Article
Genetic polymorphisms in folate metabolism and the risk of stomach cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2007
Zhang Fang Fang, Terry Mary Beth, Hou Lifang, Chen Jinbo, Lissowska Jolanta, Yeager Meredith, Zatonski Witold, Chanock Stephen, Morabia Alfredo, Chow Wong-Ho
Abstract excerpt
Folate deficiency has been implicated in the etiology of stomach cancer through abnormal DNA methylation and disrupted DNA synthesis and repair. Enzyme-coding genes involved in folate metabolism are often polymorphic. In a population-based study of 305 cases and 427 controls in Warsaw, Poland, we evaluated the risk of stomach cancer in relation to polymorphisms in folate-metabolizing genes, including MTHFR...
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