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Article

Lack of association between methionine synthase A2756G polymorphism and digestive system cancer risk: evidence from 3,9327 subjects.

PloS one - 1 Jan 2013

Zhao Yuan, Chen Zixian, Ma Yushui, Xia Qing, Zhang Feng, Fu Da, Wang Xiao-Feng

Abstract excerpt

BACKGROUND: Polymorphisms in genes involved in the metabolism of folate and methyl groups have been implicated with risk of digestive system cancer. Methionine synthase (MTR) plays a central role in folate metabolism, thereby affecting DNA methylation. The association between A2756G polymorphism (rs1805087) in MTR and digestive system cancer susceptibility was inconsistent in previous studies. To investigate this...

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Identifiers

PMID: 23613867
DOI: 10.1371/journal.pone.0061511
PMCID: PMC3629058

Genes

MTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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