Article
Probing the interaction between U24 and the SH3 domain of Fyn tyrosine kinase.
Biochemistry - 30 Sept 2014
Sang Yurou, Tait Andrew R, Scott Walter R P, Creagh A Louise, Kumar Prashant, Haynes Charles A, Straus Suzana K
Abstract excerpt
The putative membrane protein U24 from HHV-6A shares a seven-residue sequence identity (which includes a PxxP motif) with myelin basic protein (MBP), a protein responsible for the compaction of the myelin sheath in the central nervous system. U24 from HHV-6A also shares a PPxY motif with U24 from the related virus HHV-7, allowing them both to block early endosomal recycling. Recently, MBP has been shown to have...
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