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Article

Modulation of the oligomerization of myelin proteolipid protein by transmembrane helix interaction motifs.

Biochemistry - 17 Aug 2010

Ng Derek P, Deber Charles M

Abstract excerpt

Proteolipid protein (PLP) is a highly hydrophobic 276-residue integral membrane protein that constitutes more than 50% of the total protein in central nervous system myelin. Previous studies have shown that this protein exists in myelin as an oligomer rather than as a monomer, and mutations in PLP that lead to neurological disorders such as Pelizaeus-Merzbacher disease and spastic paraplegia type 2 have been...

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PMID: 20695528
DOI: 10.1021/bi100739r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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