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Article

A disorder-to-order structural transition in the COOH-tail of Fz4 determines misfolding of the L501fsX533-Fz4 mutant.

Scientific reports - 1 Jan 2013

Lemma Valentina, D'Agostino Massimo, Caporaso Maria Gabriella, Mallardo Massimo, Oliviero Giorgia, Stornaiuolo Mariano, Bonatti Stefano

Abstract excerpt

Frizzled 4 belongs to the superfamily of G protein coupled receptors. The unstructured cytosolic tail of the receptor is essential for its activity. The mutation L501fsX533 in the fz4 gene results in a new COOH-tail of the receptor and causes a form of Familial exudative vitreoretinopathy. Here w...

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Identifiers

PMID: 24036468
DOI: 10.1038/srep02659
PMCID: PMC3773625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24036468-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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