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Article

Homomeric interactions of the MPZ Ig domain and their relation to Charcot-Marie-Tooth disease.

Brain : a journal of neurology - 1 Dec 2023

Ptak Christopher P, Peterson Tabitha A, Hopkins Jesse B, Ahern Christopher A, Shy Michael E, Piper Robert C

Abstract excerpt

Mutations in MPZ (myelin protein zero) can cause demyelinating early-onset Charcot-Marie-Tooth type 1B disease or later onset type 2I/J disease characterized by axonal degeneration, reflecting the diverse roles of MPZ in Schwann cells. MPZ holds apposing membranes of the myelin sheath together, with the adhesion role fulfilled by its extracellular immunoglobulin-like domain (IgMPZ), which oligomerizes. Models for...

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Identifiers

PMID: 37542466
DOI: 10.1093/brain/awad258
PMCID: PMC10690024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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