Article
The ER-lumenal domain of the HHV-7 immunoevasin U21 directs class I MHC molecules to lysosomes.
Traffic (Copenhagen, Denmark) - 1 Dec 2003
Hudson Amy W, Blom Daniël, Howley Peter M, Ploegh Hidde L
Abstract excerpt
Like all members of the herpesvirus family, human herpesvirus-7 has evolved mechanisms to evade immune detection. The human herpesvirus-7 gene product U21 encodes an immunoevasin that binds to class I major histocompatibility complex molecules and diverts them to a lysosomal compartment. Here we show that the cytoplasmic tail of U21, although sufficient to sequester a heterologous membrane protein (CD4 chimera),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.