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Article

WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc–dependent manner

15 Sept 2014

Abstract excerpt

Hematopoiesis is fully dependent on hematopoietic stem cells (HSCs) that possess the capacity to self-renew and differentiate into all blood cell lineages. WASH, Wiskott-Aldrich syndrome protein (WASP) and SCAR homologue (WASH) is involved in endosomal sorting as an actin-nucleating protein. Here, we show that conditional WASH deletion in the hematopoietic system causes defective blood production of the host,...

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PMID: 25225459
DOI: 10.1084/jem.20140169

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