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Article

Human subtelomeric WASH genes encode a new subclass of the WASP family.

PLoS genetics - 1 Dec 2007

Linardopoulou Elena V, Parghi Sean S, Friedman Cynthia, Osborn Gregory E, Parkhurst Susan M, Trask Barbara J

Abstract excerpt

Subtelomeres are duplication-rich, structurally variable regions of the human genome situated just proximal of telomeres. We report here that the most terminally located human subtelomeric genes encode a previously unrecognized third subclass of the Wiskott-Aldrich Syndrome Protein family, whose known members reorganize the actin cytoskeleton in response to extracellular stimuli. This new subclass, which we call...

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Identifiers

PMID: 18159949
DOI: 10.1371/journal.pgen.0030237
PMCID: PMC2151093

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