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Article

Actin cytoskeletal defects in immunodeficiency.

Immunological reviews - 1 Nov 2013

Moulding Dale A, Record Julien, Malinova Dessislava, Thrasher Adrian J

Abstract excerpt

The importance of the cytoskeleton in mounting a successful immune response is evident from the wide range of defects that occur in actin-related primary immunodeficiencies (PIDs). Studies of these PIDs have revealed a pivotal role for the actin cytoskeleton in almost all stages of immune system function, from hematopoiesis and immune cell development, through to recruitment, migration, intercellular and...

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Identifiers

PMID: 24117828
DOI: 10.1111/imr.12114
PMCID: PMC3884764

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Source receipt: pubmed, retrieved 7 Sept 2026.

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