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Article

Actin cytoskeletal defects in immunodeficiency.

Immunological reviews - 1 Nov 2013

Moulding Dale A, Record Julien, Malinova Dessislava, Thrasher Adrian J

Abstract excerpt

The importance of the cytoskeleton in mounting a successful immune response is evident from the wide range of defects that occur in actin-related primary immunodeficiencies (PIDs). Studies of these PIDs have revealed a pivotal role for the actin cytoskeleton in almost all stages of immune system function, from hematopoiesis and immune cell development, through to recruitment, migration, intercellular and...

Topics

Actin Cytoskeleton
Actins
Animals
Humans
Immune System
Immunologic Deficiency Syndromes
Mutation
Wiskott-Aldrich Syndrome
Wiskott-Aldrich Syndrome Protein Family

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24117828
DOI: 10.1111/imr.12114
PMCID: PMC3884764

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