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Article

c-Jun is essential for organization of the epidermal leading edge.

Developmental cell - 1 Jun 2003

Li Guochun, Gustafson-Brown Cindy, Hanks Steven K, Nason Katie, Arbeit Jeffrey M, Pogliano Kit, Wisdom Ronald M, Johnson Randall S

Abstract excerpt

The migration of epithelial layers requires specific and coordinated organization of the cells at the leading edge of the sheet. Mice that are conditionally deleted for the c-jun protooncogene in epidermis are born at expected frequencies, but with open eyes and with defects in epidermal wound healing. Keratinocytes lacking c-Jun are unable to migrate or elongate properly in culture at the border of scratch...

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Source

Identifiers

PMID: 12791271
DOI: 10.1016/s1534-5807(03)00159-x

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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