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Regulation of EGFR nanocluster formation by ionic protein-lipid interaction.

Cell research - 1 Aug 2014

Wang Ye, Gao Jing, Guo Xingdong, Tong Ti, Shi Xiaoshan, Li Lunyi, Qi Miao, Wang Yajie, Cai Mingjun, Jiang Junguang, Xu Chenqi, Ji Hongbin, Wang Hongda

Abstract excerpt

The abnormal activation of epidermal growth factor receptor (EGFR) is strongly associated with a variety of human cancers but the underlying molecular mechanism is not fully understood. By using direct stochastic optical reconstruction microscopy (dSTORM), we find that EGFR proteins form nanoclusters in the cell membrane of both normal lung epithelial cells and lung cancer cells, but the number and size of...

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Chlorocebus aethiops
COS Cells
Epithelial Cells
HEK293 Cells
Ions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphatidylinositol 4,5-Diphosphate

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Open in PubMed Open full text

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PMID: 25001389
DOI: 10.1038/cr.2014.89
PMCID: PMC4123299

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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