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Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity

27 Aug 2019

Abstract excerpt

Alzheimer's disease is the most prevalent neurodegenerative disorder leading to progressive cognitive decline. Despite decades of research, understanding AD progression at the molecular level, especially at its early stages, remains elusive. Here, we identified several presymptomatic AD markers by investigating brain proteome changes over the course of neurodegeneration in a transgenic mouse model of AD...

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PMID: 31453805
DOI: 10.7554/elife.47498

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