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Article

Synergistic effect of heme oxygenase-1 and tau genetic variants on Alzheimer's disease risk.

Dementia and geriatric cognitive disorders - 1 Jan 2008

Mateo Ignacio, Sánchez-Juan Pascual, Rodríguez-Rodríguez Eloy, Infante Jon, Vázquez-Higuera José Luis, García-Gorostiaga Inés, Berciano José, Combarros Onofre

Abstract excerpt

Oxidative stress plays a role in tau hyperphosphorylation and the development of neurofibrillary tangles (NFT). In Alzheimer's disease (AD) brain, accumulation of hyperphosphorylated tau in NFT is associated with the induction of heme oxygenase-1 (HO-1), a potent antioxidant that downregulates th...

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Identifiers

PMID: 18841019
DOI: 10.1159/000161059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18841019-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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