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Article

The effects of age, genotype and diet on hippocampal subfield iron dysregulation and Alzheimer's disease biomarkers in an ApoE mouse model.

The European journal of neuroscience - 1 Mar 2023

Black Elisabeth, Rasch Abbey, Wimmer Tyler, Li Alivia, Araujo Amanda, Cieslak Steve, Steed Kevin S, Adhikari Rajan D, Wisco Jonathan J, Hutchinson Bre Anna

Abstract excerpt

Current theories regarding accumulation of Alzheimer's disease-related deposits of abnormal intra- and extracellular proteins include reactions to inflammation and mitochondrial dysfunction. In this study, we explored whether age, genotype and inflammation via diet have a greater effect on dysregulatory protein accumulation in any particular subfield of the hippocampus. We stained for ferritin, ferroportin,...

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PMID: 36775930
DOI: 10.1111/ejn.15933

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