Metallothionein‐I/II expression associates with the astrocyte DNA damage response and not Alzheimer‐type pathology in the aging brain

Abstract excerpt

Abstract Oxidative stress and oxidative DNA damage are early features of mild cognitive impairment and Alzheimer's disease (AD), occurring before the formation of classical AD neuropathology, and resulting from an imbalance between pro‐ and anti‐oxidants. Astrocytes play a major neuroprotective role, producing high levels of anti‐oxidants including metallothionein‐I and ‐II (MT‐I/II). In the present study we...

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