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Article

Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age.

Free radical biology & medicine - 15 Nov 2008

Abdul Hafiz Mohmmad, Sultana Rukhsana, St Clair Daret K, Markesbery William R, Butterfield D Allan

Abstract excerpt

Oxidative stress is strongly implicated in the progressive decline of cognition associated with aging and neurodegenerative disorders. In the brain, free radical-mediated oxidative stress plays a critical role in the age-related decline of cellular function as a result of the oxidation of proteins, lipids, and nucleic acids. A number of studies indicate that an increase in protein oxidation and lipid peroxidation...

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Identifiers

PMID: 18762245
DOI: 10.1016/j.freeradbiomed.2008.08.012
PMCID: PMC2597707

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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