Article
Single nucleotide polymorphisms in AREG and EREG are prognostic biomarkers in locally advanced gastric cancer patients after surgery with curative intent.
Pharmacogenetics and genomics - 1 Nov 2014
Wakatsuki Takeru, Stintzing Sebastian, Zhang Wu, Yang Dongyun, Azuma Mizutomo, Ning Yan, Yamauchi Shinichi, Matsusaka Satoshi, Volz Nico B, Sunakawa Yu, Koizumi Wasaburo, Watanabe Masahiko, Barzi Afsaneh, El Khoueiry Anthony B, Shah Manish A, Lenz Heinz-Josef
Abstract excerpt
OBJECTIVE: Amphiregulin (AREG) and epiregulin (EREG) are important ligands to the epithelial growth factor receptor, which is involved in the regulation of progression and stemness in gastric cancer (GC). This study investigated whether frequent single nucleotide polymorphisms (SNPs) in genes of AREG and EREG are associated with recurrence-free survival and overall survival in patients with locally advanced GC....
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