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Article

Prognostic value of amphiregulin and epiregulin mRNA expression in metastatic colorectal cancer patients.

Oncotarget - 23 Aug 2016

Jing Chen, Jin Yang Han, You Zhai, Qiong Qian, Jun Zhou

Abstract excerpt

Epidermal growth factor receptor (EGFR) and its ligands amphiregulin (AREG) and epiregulin (EREG) play a central role in the development of colorectal cancer, but the prognostic values of AREG and EREG are controversial. We conducted a meta-analysis of studies that investigated AREG and/or EREG mRNA levels in primary tumors to determine their prognostic value in metastatic colorectal cancer (mCRC). In addition,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27344184
DOI: 10.18632/oncotarget.10151
PMCID: PMC5342459

Genes

AREG
EREG
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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