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Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer

25 Sept 2018

Abstract excerpt

Expression of the epidermal growth factor ligands amphiregulin (AREG) and epiregulin (EREG) is positively correlated with a response to EGFR-targeted therapies in colorectal cancer. Gene-body methylation sites, which show a strong inverse correlation with AREG and EREG gene expression, were identified in cell lines using targeted 454 FLX-bisulfite sequencing and SIRPH analyses for AREG/EREG promoters and...

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PMID: 30252132
DOI: 10.1002/ijc.31892

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