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Article

ERCC1 and ERCC2 variants predict survival in gastric cancer patients.

PloS one - 1 Jan 2013

Li Yangkai, Liu Zhensheng, Liu Hongliang, Wang Li-E, Tan Dongfeng, Ajani Jaffer A, Wei Qing-Yi

Abstract excerpt

PURPOSE: ERCC1 and ERCC2 play critical roles in the nucleotide excision repair pathway that effectively repairs DNA damage induced by chemotherapeutic agents. Therefore, functional single nucleotide polymorphisms (SNPs) in these genes could have an impact on clinical outcomes in cancer patients who received chemotherapy. However, few studies have simultaneously investigated the roles of ERCC1 and ERCC2 SNPs in...

Topics

Adult
Aged
Aged, 80 and over
DNA-Binding Proteins
Endonucleases
Female
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Proportional Hazards Models

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stomach Neoplasms

Xeroderma Pigmentosum Group D Protein

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 24023723
DOI: 10.1371/journal.pone.0071994
PMCID: PMC3759385

Genes

ERCC2
ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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