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Article

Intergenic polymorphisms in the amphiregulin gene region as biomarkers in metastatic colorectal cancer patients treated with anti-EGFR plus irinotecan.

The pharmacogenomics journal - 1 Jun 2014

Sebio A, Páez D, Salazar J, Berenguer-Llergo A, Paré-Brunet L, Lasa A, Del Río E, Tobeña M, Martín-Richard M, Baiget M, Barnadas A

Abstract excerpt

In the epidermal growth factor receptor (EGFR) pathway, polymorphisms in EGFR and its ligand EGF have been studied as biomarkers for anti-EGFR treatment. However, the potential pharmacogenetic role of other EGFR ligands such as amphiregulin (AREG) and epiregulin (EREG) has not been elucidated. We studied 74 KRAS and BRAF wild-type metastatic colorectal cancer patients treated with anti-EGFR plus irinotecan....

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Source

Identifiers

PMID: 23959273
DOI: 10.1038/tpj.2013.29

Genes

EGFR
AREG
EGF
EREG
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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