Article
A lymphatic defect causes ocular hypertension and glaucoma in mice.
The Journal of clinical investigation - 1 Oct 2014
Thomson Benjamin R, Heinen Stefan, Jeansson Marie, Ghosh Asish K, Fatima Anees, Sung Hoon-Ki, Onay Tuncer, Chen Hui, Yamaguchi Shinji, Economides Aris N, Flenniken Ann, Gale Nicholas W, Hong Young-Kwon, Fawzi Amani, Liu Xiaorong, Kume Tsutomu, Quaggin Susan E
Abstract excerpt
Glaucoma is a leading cause of blindness, afflicting more than 60 million people worldwide. Increased intraocular pressure (IOP) due to impaired aqueous humor drainage is a major risk factor for the development of glaucoma. Here, we demonstrated that genetic disruption of the angiopoietin/TIE2 (ANGPT/TIE2) signaling pathway results in high IOP, buphthalmos, and classic features of glaucoma, including retinal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.