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Article

The Schlemm’s canal is a VEGF-C/VEGFR-3–responsive lymphatic-like vessel

24 Jul 2014

Abstract excerpt

In glaucoma, aqueous outflow into the Schlemm's canal (SC) is obstructed. Despite striking structural and functional similarities with the lymphatic vascular system, it is unknown whether the SC is a blood or lymphatic vessel. Here, we demonstrated the expression of lymphatic endothelial cell markers by the SC in murine and zebrafish models as well as in human eye tissue. The initial stages of SC development...

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PMID: 25061878
DOI: 10.1172/jci75395

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