Article
Glaucoma-Protective Human Single-Nucleotide Polymorphism in the Angpt2 Locus Increased ANGPT2 Expression and Schlemm Canal Area in Mice-Brief Report.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2024
Kiyota Naoki, Onay Tuncer, Leeaw Phoebe, Liu Pan, Deb Dilip K, Thomson Benjamin R, Segrè Ayellet V, Wiggs Janey L, Quaggin Susan E
Abstract excerpt
BACKGROUND: The ANGPT (angiopoietin)-TEK (tyrosine kinase, endothelial) vascular signaling pathway plays a key role in the formation of Schlemm canal, and loss-of-function mutations in the TEK or ANGPT1 gene are associated with primary congenital glaucoma in children. In genome-wide association studies, an association was identified between protection from primary open-angle glaucoma and the single-nucleotide...
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