Article
Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development.
Human molecular genetics - 12 Apr 2000
Smith R S, Zabaleta A, Kume T, Savinova O V, Kidson S H, Martin J E, Nishimura D Y, Alward W L, Hogan B L, John S W
Abstract excerpt
Anterior segment developmental disorders, including Axenfeld-Rieger anomaly (ARA), variably associate with harmfully elevated intraocular pressure (IOP), which causes glaucoma. Clinically observed dysgenesis does not correlate with IOP, however, and the etiology of glaucoma development is not understood. The forkhead transcription factor genes Foxc1 (formerly Mf1 ) and Foxc2 (formerly Mfh1 ) are expressed in the...
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