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Article

Angiopoietin-1 Knockout Mice as a Genetic Model of Open-Angle Glaucoma

18 Mar 2020

Abstract excerpt

Purpose: conditional knockout mice may provide one such model. Angiopoietin/TEK (ANGPT/TEK) signaling is crucial for SC formation and integrity in mice and humans, and mice lacking TEK or its ligand ANGPT1 develop a hypomorphic SC insufficient for normal aqueous humor outflow. Methods: inducible knockout mice, especially focusing on retina morphology and function. Results: deletion resulted in persistent ocular...

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PMID: 32818103
DOI: 10.1167/tvst.9.4.16

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