Article
Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth.
Proceedings of the National Academy of Sciences of the United States of America - 7 Feb 2012
Seo Seungwoon, Singh Hardeep P, Lacal Pedro M, Sasman Amy, Fatima Anees, Liu Ting, Schultz Kathryn M, Losordo Douglas W, Lehmann Ordan J, Kume Tsutomu
Abstract excerpt
Normal vision requires the precise control of vascular growth to maintain corneal transparency. Here we provide evidence for a unique mechanism by which the Forkhead box transcription factor FoxC1 regulates corneal vascular development. Murine Foxc1 is essential for development of the ocular anterior segment, and in humans, mutations have been identified in Axenfeld-Rieger syndrome, a disorder characterized by...
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