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Article

Mechanisms of mutant p53 stabilization in cancer.

Sub-cellular biochemistry - 1 Jan 2014

Frum Rebecca A, Grossman Steven R

Abstract excerpt

p53 transactivates cell cycle inhibitory, apoptosis or senescence-related genes in response to DNA damage to protect the genetic integrity of the cell. Highlighting its critical tumor suppressor functions, p53 is mutated, lost, or functionally inactivated in nearly all cancers. When mutated within its core DNA binding domain, p53's normal instability is abrogated, and oncogenic gain-of-function properties are...

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PMID: 25201195
DOI: 10.1007/978-94-017-9211-0_10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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