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Regulators of Oncogenic Mutant TP53 Gain of Function

20 Dec 2018

Abstract excerpt

The tumor suppressor p53 (TP53) is the most frequently mutated human gene. Mutations in TP53 not only disrupt its tumor suppressor function, but also endow oncogenic gain-of-function (GOF) activities in a manner independent of wild-type TP53 (wtp53). Mutant TP53 (mutp53) GOF is mainly mediated by its binding with other tumor suppressive or oncogenic proteins. Increasing evidence indicates that stabilization of...

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PMID: 30577483
DOI: 10.3390/cancers11010004

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