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p53: Multiple Facets of a Rubik's Cube

4 Nov 2016

Abstract excerpt

The p53 tumor suppressor has been studied for decades, and still there are many questions left unanswered. In this review, we first describe the current understanding of the wild-type p53 functions that determine cell survival or death, and regulation of the protein, with a particular focus on the negative regulators, the murine double minute family of proteins. We also summarize tissue-, stress-, and...

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PMID: 30775651
DOI: 10.1146/annurev-cancerbio-050216-121926

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