Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant p53 in cancer: from molecular mechanism to therapeutic modulation.

Cell death & disease - 18 Nov 2022

Chen Xiaohua, Zhang Taotao, Su Wei, Dou Zhihui, Zhao Dapeng, Jin Xiaodong, Lei Huiwen, Wang Jing, Xie Xiaodong, Cheng Bo, Li Qiang, Zhang Hong, Di Cuixia

Abstract excerpt

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel oncogenic functions, which is termed "gain-of-function". Emerging evidence suggests that mutp53 is highly associated with advanced malignancies and poor prognosis, which makes it a target for development of novel cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Mutation

Share to Neoplasms

Share to RNA modifications and cancer

Share to Tumor Microenvironment

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 36400749
DOI: 10.1038/s41419-022-05408-1
PMCID: PMC9674619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant p53 in cancer: from molecular mechanism to therapeutic modulation.PMID 36400749Read ↗

Recent findings on the role of wild-type and mutant p53 in cancer development and therapySemantic proximity Read ↗

Gain-of-function mutant p53 in cancer progression and therapySemantic proximity Read ↗

p53: from understanding its structure to advances in therapeutic targeting.Semantic proximity Read ↗

Mutant p53 in Cancer Progression and Targeted TherapiesSemantic proximity Read ↗

Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer.Semantic proximity Read ↗

Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy.Semantic proximity Read ↗

Wild-type and mutant p53 in cancer-related ferroptosis. A matter of stress management?Semantic proximity Read ↗

TP53 mutations in cancer: Molecular features and therapeutic opportunities (Review).Semantic proximity Read ↗

Recent Advances on Mutant p53: Unveiling Novel Oncogenic Roles, Degradation Pathways, and Therapeutic Interventions.Semantic proximity Read ↗

Tumor suppressor p53 and its gain-of-function mutants in cancer.Semantic proximity Read ↗

A Balancing Act: p53 Activity from Tumor Suppression to Pathology and Therapeutic ImplicationsSemantic proximity Read ↗

Mutant p53 in cancer therapy—the barrier or the pathSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.