Article

Ribosome Profiling Reveals Translational Reprogramming via mTOR Activation in Omacetaxine Resistant Multiple Myeloma

2024-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Protein homeostasis is critical to the survival of multiple myeloma (MM) cells. While this is targeted with proteasome inhibitors, mRNA translation inhibition has not entered trials. Recent work illustrates broad sensitivity MM cells to translation inhibitor omacetaxine. We hypothesized that understanding how MM cells become omacetaxine resistant will lead to the development of drug combinations...

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Literature Corpus work: aa508e7e-9a5e-5ecc-89b2-3c058e492c59
DOI: 10.1101/2024.04.23.590843

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