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Article

Exploiting Protein Translation Dependence in Multiple Myeloma with Omacetaxine-Based Therapy

27 Oct 2020

Abstract excerpt

Abstract Purpose: The prognosis of patients with multiple myeloma who are resistant to proteasome inhibitors, immunomodulatory drugs (IMiD), and daratumumab is extremely poor. Even B-cell maturation antigen–specific chimeric antigen receptor T-cell therapies provide only a temporary benefit before patients succumb to their disease. In this article, we interrogate the unique sensitivity of multiple myeloma cells...

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Identifiers

PMID: 33109736
DOI: 10.1158/1078-0432.ccr-20-2246

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