Article
RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma.
British journal of haematology - 1 Apr 2017
Lee Hans C, Wang Hua, Baladandayuthapani Veerabhadran, Lin Heather, He Jin, Jones Richard J, Kuiatse Isere, Gu Dongmin, Wang Zhiqiang, Ma Wencai, Lim John, O'Brien Sean, Keats Jonathan, Yang Jing, Davis Richard E, Orlowski Robert Z
Abstract excerpt
Dysregulation of MYC is frequently implicated in both early and late myeloma progression events, yet its therapeutic targeting has remained a challenge. Among key MYC downstream targets is ribosomal biogenesis, enabling increases in protein translational capacity necessary to support the growth and self-renewal programmes of malignant cells. We therefore explored the selective targeting of ribosomal biogenesis...
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