Article

Targeting the ribosome to treat multiple myeloma

2023-11-10

Abstract excerpt

<title>Abstract</title> <p>The high rates of protein synthesis and processing render multiple myeloma (MM) cells vulnerable to perturbations in protein homeostasis. The induction of proteotoxic stress by targeting protein degradation with proteasome inhibitors (PI) has revolutionized the treatment of MM. However, resistance to PI is inevitable and represents an ongoing clinical challenge. Our first-in-human study...

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Literature Corpus work: f990e7cd-1b15-57f2-97fc-4f8b679c289b
DOI: 10.21203/rs.3.rs-3582717/v1

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