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Article

Neural Crest-Specific TSC1 Deletion in Mice Leads to Sclerotic Craniofacial Bone Lesion.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2015

Fang Fang, Sun Shaogang, Wang Li, Guan Jun-Lin, Giovannini Marco, Zhu Yuan, Liu Fei

Abstract excerpt

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in either TSC1 or TSC2. TSC has high frequency of osseous manifestations such as sclerotic lesions in the craniofacial region. However, an animal model that replicates TSC craniofacial bone lesions has not yet...

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Source

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Identifiers

PMID: 25639352
DOI: 10.1002/jbmr.2447
PMCID: PMC4478231

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25639352-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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