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Article

The N-terminal CEBPA mutant in acute myeloid leukemia impairs CXCR4 expression.

Haematologica - 1 Dec 2014

Kuo Yuan-Yeh, Hou Hsin-An, Chen Yin-Kai, Li Li-Yu, Chen Po-Hsuen, Tseng Mei-Hsuan, Huang Chi-Fei, Lee Fen-Yu, Liu Ming-Chih, Liu Chia-Wen, Chou Wen-Chien, Liu Chieh-Yu, Tang Jih-Luh, Yao Ming, Tien Hwei-Fang

Abstract excerpt

CXC chemokine receptor 4 (CXCR4) is an essential regulator for homing and maintenance of hematopoietic stem cells within the bone marrow niches. Analysis of clinical implications of bone marrow CXCR4 expression in patients with acute myeloid leukemia showed not only higher CXCR4 expression was an independent poor prognostic factor, irrespective of age, white blood cell counts, cytogenetics, and mutation status of...

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Identifiers

PMID: 25193961
DOI: 10.3324/haematol.2014.107821
PMCID: PMC4258761

Genes

CXCR4
FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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