Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Granulopoiesis Requires Increased C/EBPα Compared to Monopoiesis, Correlated with Elevated Cebpa in Immature G-CSF Receptor versus M-CSF Receptor Expressing Cells

21 Apr 2014

Abstract excerpt

C/EBPα is required for the formation of granulocyte-monocyte progenitors; however, its role in subsequent myeloid lineage specification remains uncertain. Transduction of murine marrow with either of two Cebpa shRNAs markedly increases monocyte and reduces granulocyte colonies in methylcellulose or the monocyte to neutrophil ratio in liquid culture. Similar findings were found after marrow shRNA transduction and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Blood disorders and treatments
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24752325
DOI: 10.1371/journal.pone.0095784

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Granulopoiesis Requires Increased C/EBPα Compared to Monopoiesis, Correlated with Elevated Cebpa in Immature G-CSF Receptor versus M-CSF Receptor Expressing CellsPMID 24752325Read ↗

C/EBPα in normal and malignant myelopoiesis.Semantic proximity Read ↗

C/EBPα deregulation as a paradigm for leukemogenesis.Semantic proximity Read ↗

Expression and regulation of C/EBPα in normal myelopoiesis and in malignant transformation.Semantic proximity Read ↗

C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations.Semantic proximity Read ↗

Human C/EBP-ϵ activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiationSemantic proximity Read ↗

Induction of C/EBPα activity alters gene expression and differentiation of human CD34+ cellsSemantic proximity Read ↗

The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression.Semantic proximity Read ↗

Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis.Semantic proximity Read ↗

The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets FactorsSemantic proximity Read ↗

C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemiaSemantic proximity Read ↗

Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-Initiating Cells in C/EBPα Mutant AMLSemantic proximity Read ↗

A C/ebpα isoform-specific differentiation program in primary myelocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.