Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human C/EBP-ϵ activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiation

2 Oct 2008

Abstract excerpt

CCAAT enhancer-binding protein-epsilon (C/EBP-epsilon) is required for the terminal differentiation of neutrophils and eosinophils. Human C/EBP-epsilon is expressed as 4 isoforms (32, 30, 27, and 14 kDa) through differential RNA splicing, and alternative promoters and translational start sites. The C/EBP-epsilon(32/30) isoforms are transcriptional activators, whereas C/EBP-epsilon(27) interacts with and represses...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Immune Cell Function and Interaction
Share to Invertebrate Immune Response Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18832658
DOI: 10.1182/blood-2008-02-139741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human C/EBP-ϵ activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiationPMID 18832658Read ↗

Novel Combinatorial Interactions of GATA-1, PU.1, and C/EBPε Isoforms Regulate Transcription of the Gene Encoding Eosinophil Granule Major Basic ProteinSemantic proximity Read ↗

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient miceSemantic proximity Read ↗

CCAAT/enhancer binding protein ɛ is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicingSemantic proximity Read ↗

Granulocyte colony-stimulating factor regulates myeloid differentiation through CCAAT/enhancer-binding protein epsilonSemantic proximity Read ↗

N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation.Semantic proximity Read ↗

Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon.Semantic proximity Read ↗

C/EBPϵ interacts with retinoblastoma and E2F1 during granulopoiesisSemantic proximity Read ↗

C/EBPα in normal and malignant myelopoiesis.Semantic proximity Read ↗

The Role of C/EBPε in the Terminal Stages of Granulocyte DifferentiationSemantic proximity Read ↗

Expression and regulation of C/EBPα in normal myelopoiesis and in malignant transformation.Semantic proximity Read ↗

A C/ebpα isoform-specific differentiation program in primary myelocytesSemantic proximity Read ↗

The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets FactorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.